Test/Profile Name
Anti Thyroid Peroxidase (TPO)(Microsoml)Test/Profile Code
T000428Clinical Usefullness
Aiding in the diagnosis of thyroid autoimmune disorders
Differentiating thyroid autoimmune disorders from nonautoimmune.
Goiter or hyperthyroidism as a diagnostic tool in deciding whether to treat a patient who has subclinical hypothyroidism.
Synonyms (Also knowns as)
Thyroid Peroxidase Antibody
TPO (Thyroid Oxidase)Antibodies
Thyroid Antibody Group
Thyroid Microsomal Antibodies
Antithyroid Antibodies
Microsomal Antibodies
Hashimoto Disease
Specimen Type and Minimal Volume
Serum 1 mlSerum : Plain Tube (Red Top)
Forms
Not requiredTest Equipment
Abbott Architect i 2000 SRTest Method
Chemiluminescent microparticle immunoassy (CMIA)Reference Range
0.5 -5.61 IU/ML
Include Test
N/AReporting Time (Turn Around Time; TAT)
8 hrsClinical Information
In patients with subclinical hypothyroidism, the presence of thyroperoxidase (TPO) antibodies predicts a higher risk of developing overt hypothyroidism, 4.3% per year versus 2.1% per year in antibody-negative individuals. Furthermore, it raises the concern that such patients may be at increased risk of developing other autoimmune diseases, such as adrenal insufficiency and type 1 diabetes.
The frequency of detectable anti-TPO observed in nonimmune thyroid disease is similar to the 10% to 12% observed in a healthy population with normal thyroid function.
There is a good association between the presence of autoantibodies against TPO and histological thyroiditis. However, in view of the extensive regenerative capacity of the thyroid under the influence of thyroid-stimulating hormone, chronic thyroid disease may be present for years before the clinical manifestation of hypothyroidism becomes evident, if ever.
Related Disease/Condition
Hashimoto thyroiditisIdiopathic myxedema
Graves diseas
Thyroid Diseases
Thyroid Cancer
Autoimmune Disorders
Related Test
Anti thyroglobulin AntibodyFree T3 and Total T3
Free T4
TSH
Thyroglobulin