Anti Thyroid Peroxidase (TPO)(Microsoml)

Test/Profile Name

Anti Thyroid Peroxidase (TPO)(Microsoml)

Test/Profile Code


Clinical Usefullness

Aiding in the diagnosis of thyroid autoimmune disorders

Differentiating thyroid autoimmune disorders from nonautoimmune.

Goiter or hyperthyroidism as a diagnostic tool in deciding whether to treat a patient who has subclinical hypothyroidism.

Synonyms (Also knowns as)

Thyroid Peroxidase Antibody  

TPO (Thyroid Oxidase)Antibodies 

Thyroid Antibody Group 

Thyroid Microsomal  Antibodies 

Antithyroid Antibodies  

Microsomal Antibodies 

Hashimoto Disease

Specimen Type and Minimal Volume

Serum 1 ml
Serum : Plain Tube (Red Top)


Not required

Test Equipment

Abbott Architect i 2000 SR

Test Method

Chemiluminescent microparticle immunoassy (CMIA)

Reference Range

0.5 -5.61 IU/ML

Include Test


Reporting Time (Turn Around Time; TAT)

8 hrs

Clinical Information

In patients with subclinical hypothyroidism, the presence of thyroperoxidase (TPO) antibodies predicts a higher risk of developing overt hypothyroidism, 4.3% per year versus 2.1% per year in antibody-negative individuals. Furthermore, it raises the concern that such patients may be at increased risk of developing other autoimmune diseases, such as adrenal insufficiency and type 1 diabetes.

The frequency of detectable anti-TPO observed in nonimmune thyroid disease is similar to the 10% to 12% observed in a healthy population with normal thyroid function.

There is a good association between the presence of autoantibodies against TPO and histological thyroiditis. However, in view of the extensive regenerative capacity of the thyroid under the influence of thyroid-stimulating hormone, chronic thyroid disease may be present for years before the clinical manifestation of hypothyroidism becomes evident, if ever.

Related Disease/Condition

Hashimoto thyroiditis
Idiopathic myxedema
Graves diseas
Thyroid Diseases
Thyroid Cancer
Autoimmune Disorders

Related Test

Anti thyroglobulin Antibody
Free T3 and Total T3
Free T4