Anti Thyroglobulin Antibody (ATA)

Test/Profile Name

Anti Thyroglobulin Antibody (ATA)

Test/Profile Code

T000427

Clinical Usefullness

Used to  diagnosis of autoimmune thyroid disease.

Synonyms (Also knowns as)

Anti-Thyroglobulin Antibody

TG (Thyroglobulin) Antibody

Thyroglobulin Antibody

Specimen Type and Minimal Volume

Serum 1 ml
Serum : Plain Blood (Red Top)

Forms

Not required

Test Equipment

Abbott Architect i 1000 SR

Test Method

Chemiluminescent microparticle immunoassy (CMIA)

Reference Range

0  -   4.11    IU/mL

Include Test

N/A

Reporting Time (Turn Around Time; TAT)

8 hrs

Clinical Information

Thyroglobulin is a glycoprotein of 670,000 daltons, which is comprised of two identical subunits and represents the major protein found in the thyroid. This protein provides 40 tyrosine residues, of the 140 in the molecule, used for iodination during the biosynthesis of thyroxine (T4) and triiodothyronine (T3) and, therefore, is responsible for the accumulation of iodine by the thyroid gland.

Although anti-Tg are found in conjunction with anti-TPO in the majority of cases of Hashimoto’s thyroiditis, Primary Myxedema and Graves’ disease, up to 1% of cases of hypothyroidism are associated with anti-Tg alone. Anti-Tg are associated with cases of mild hypothyroidism or hyperthyroidism, and are frequently found in patients with other autoimmune diseases such as Rheumatoid Arthritis, Pernicious Anaemia and Type I Diabetes. Anti-Tg are detected in 30-60% of cases of thyroid carcinoma patients. In such patients, measurement of Tg antigen must take into account the likelihood of the presence of significant levels of anti-Tg, since measurement and detection of Tg antigen may be influenced by the presence of anti-Tg. 

Furthermore, low levels of anti-Tg are also found in up to 20% of asymptomatic individuals, particularly the elderly and more often in women than men, although the clinical significance of these autoantibodies is unclear.

Related Disease/Condition

Thyroid Diseases
Thyroid Cancer
Graves Disease
Hashimoto Thyroiditis
Autoimmune Disorders

Related Test

Free T3 and Total T3
Free T4
TSH
Thyroglobulin