Test/Profile NameAnti Ganglioside IgG Antibody Profile
Among the immune-mediated peripheral neuropathies, autoantibodies to gangliosides represent an important class of noncancer-associated autoimmune peripheral neuropathies. Gangliosides are glycosphingolipids that contain sialic acid and are present in many cell types most abundantly within neural tissues along their linings (myelin). The specific carbohydrates which are recognised by these antibodies are also found in infectious organisms such as campylobacter which can trigger some of these diseases. Guillain-Barre syndrome is characterised by the presence of antibodies to membrane gangliosides including GM1, asialoGM1, LM1 and GD1b. Anti-glycolipid antibodies are associated with several distinct peripheral nerve syndromes: Multifocal motor neuropathy is associated with anti-GM1, -GA1 and -GD1b IgM antibodies. Chronic ataxic neuropathy with ophthalmoplegia M-protein, cold agglutination, and disialosyl antibodies (acronym: CANOMAD) is associated with anti-GD1b and related IgM antibodies. Miller Fisher syndrome is associated with anti-GQ1b and -GT1a IgG antibodies. The Guillain–Barré Syndrome variant Acute motor axonal neuropathy (AMAN) is associated with anti-GM1 and -GD1a IgG antibodies.
Specimen Type and Minimal VolumeVariable Please confirm with the laboratory prior to testing.