Anti Jo-1 Antibody

Test/Profile Name

Anti Jo-1 Antibody

Test/Profile Code


Clinical Usefullness

Jo 1 (histidyl tRNA synthetase) antibody test is useful in evaluating patients with signs and symptoms compatible with a connective tissue disease, especially those patients with muscle pain and limb weakness, concomitant pulmonary signs and symptoms, Raynaud phenomenon, and arthritis.

Jo 1 antibodies are a marker for the disease polymyositis, and occur most commonly in myositis patients who also have interstitial lung disease. The antibodies occur in up to 50% of patients with interstitial pulmonary fibrosis and symmetrical polyarthritis. Testing for antibodies to Jo 1 is not useful in patients with a negative test for antinuclear antibodies. A negative test for Jo 1 antibodies does not exclude the diagnosis of polymyositis or dermatomyositis.

Specimen Type and Minimal Volume

Variable Please confirm with the laboratory prior to testing.

Include Test