Test/Profile NameAnti Neuronal Antibody
Anti-neuronal antibodies are present in the serum of patients with paraneoplastic disorders affecting the nervous system. These disorders have a very wide range of clinical presentations and often enter the differential diagnosis of complex neurological problems. Negative results do not preclude the possibility of an underlying paraneoplastic disorders. Strongly positive results in appropriate clinical circumstances should lead to a thorough search for an appropriate underlying neoplasm (tumor), although this search may ultimately be negative. In many human sera from individuals unaffected by paraneoplastic syndromes, low levels of antibody to paraneoplastic antigens may be detected using very sensitive assays; these results must be carefully considered along with the clinical findings in individual patients in order to assess their significance. Some examples of Anti-neuronal antibodies/ antigen are:
*Amphiphysin - Associated with tumours of the breast or SCLC (Small cell lung carcinoma) leading to opsoclonus, ataxia
*Anti-Hu - Type I anti-neuronal nuclear antibody (ANNA-1) is associated with SCLC, resulting in paraneoplastic encephalomyelitis.
Specimen Type and Minimal VolumeVariable Please confirm with the laboratory prior to testing.